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Hydroxymethyl butyrate (HMB)
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Hydroxymethylbutyrate/Drug Interactions:- AntihypertensivesAntihypertensives: In human research, HMB supplementation reduced systolic blood pressure (diastolic blood pressure was unaffected) (2).
- AntilipemicsAntilipemics: In human research, HMB supplementation lowered total and LDL cholesterol (2).
- Antiobesity agentsAntiobesity agents: In human research, HMB supplementation has been found to increase fat loss and increase lean body mass (18; 16).
- Antiviral agentsAntiviral agents: In human research, HMB supplementation in combination with arginine and glutamine reduced HIV viral load (3).
- ImmunosuppressantsImmunosuppressants: Based on human research, HMB supplementation may stimulate the immune system (2). In human research, HMB supplementation increased basophils (10), lymphocytes, and eosinophils (15). In human research, a combination of HMB, arginine, and glutamine increased CD3 and CD8 cells (3).
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Hydroxymethylbutyrate/Herb/Supplement Interactions:- AntilipemicsAntilipemics: In human research, HMB supplementation lowered total and LDL cholesterol (2).
- Antiobesity herbs and supplementsAntiobesity herbs and supplements: In human research, HMB supplementation has been found to increase fat loss and increase lean body mass (18), particularly when used with creatine (16).
- AntiviralsAntivirals: Human research has demonstrated a decrease in the HIV viral load with HMB/arginine/glutamine supplementation in patients with HIV (3).
- ArginineArginine: In human research, HMB supplementation in combination with arginine and glutamine reduced HIV viral load (3). In human research, a combination of HMB, arginine, and glutamine increased CD3 and CD8 cells (3).
- Athletic performance enhancersAthletic performance enhancers: Based on findings from human research, HMB supplementation may have positive effects on exercise performance by increasing the onset of blood lactate accumulation (18).
- CreatineCreatine: In human research, HMB supplementation has been found to increase fat loss and increase lean body mass (18), particularly when used with creatine (16).
- GlutamineGlutamine: In human research, HMB supplementation in combination with arginine and glutamine reduced HIV viral load (3). In human research, a combination of HMB, arginine, and glutamine increased CD3 and CD8 cells (3).
- HypotensivesHypotensives: In human research, HMB supplementation reduced systolic blood pressure (diastolic blood pressure was unaffected) (2).
- ImmunostimulantsImmunostimulants: In human research, HMB supplementation in combination with arginine and glutamine reduced HIV viral load (3). In human research, HMB supplementation increased basophils (10), lymphocytes, and eosinophils (15). In human research, a combination of HMB, arginine, and glutamine increased CD3 and CD8 cells (3).
- ImmunosuppressantsImmunosuppressants: Based on human research, HMB supplementation may stimulate the immune system (2). In human research, HMB supplementation increased basophils (10), lymphocytes, and eosinophils (15). In human research, a combination of HMB, arginine, and glutamine increased CD3 and CD8 cells (3).
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Hydroxymethylbutyrate/Food Interactions:- SugarSugar: In human research, HMB absorption was slightly lower when consumed with glucose (19).
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Hydroxymethylbutyrate/Lab Interactions:- Blood pressureBlood pressure: In human research, HMB supplementation reduced systolic blood pressure (diastolic blood pressure was unaffected) (2).
- Blood urea nitrogen (BUN)tBlood urea nitrogen (BUN): In human research, HMB supplementation increased blood urea nitrogen (BUN) (15).
- CortisolCortisol: In human research, HMB supplementation decreased cortisol levels (20).
- Creatine kinaseCreatine kinase: In human research, HMB supplementation has been shown to prevent exercise-induced increases in creatine kinase (20; 10; 16; 21; 4; 1).
- HIV viral loadHIV viral load: In human research, a combination of HMB, arginine, and glutamine decreased HIV viral load (3).
- Lactate dehydrogenase (LDH)Lactate dehydrogenase (LDH): In humans, HMB supplementation decreased lactate dehydrogenase (LDH) (21).
- Lipid profileLipid profile: In human research, HMB supplementation lowered total and LDL cholesterol (2).
- Plasma ureaPlasma urea: In human research, HMB supplementation decreased plasma urea (16).
- Red blood cellsRed blood cells: In human research, HMB supplementation increased red blood cells, including hemoglobin and hematocrit (15).
- Urine urea nitrogenUrine urea nitrogen: In human research, HMB supplementation decreased urine urea nitrogen (16).
- White blood cellsWhite blood cells: In human research, HMB supplementation increased basophils (10), lymphocytes, and eosinophils (15). In human research, a combination of HMB, arginine, and glutamine increased CD3 and CD8 cells (3).
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Copyright © 2011 Natural Standard (www.naturalstandard.com)
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The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.
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